Discovery Biology Scientist

Jan 11, 2022View PDF

Responsibilities:

  • Lead and contribute to one or more early discovery and pipeline programs.
  • Design and implement the high-throughput screening assays for the drug target discovery.
  • Design and perform a variety of in vitro and ex vivo assays in tumor cell biology and/or immunology for targe validation, proof-of-concept mechanism, and therapeutic assessment.
  • Work with CROs to design and execute the in vivo MOA, efficacy, and tox studies.
  • Maintain laboratory records, summarize and present data in group meetings.
  • Draft scientific reports and regulatory documents.
  • Participate in the management of laboratory inventory and equipment maintenance.
  • Comply with laboratory safety policies.
  • Other tasks and duties as assigned.

Qualifications:

  • D. in Immunology, Molecular Biology, Cell Biology, Pharmacology, Animal Sciences, or related fields.
  • Hands-on experience in cell-based in vitro assays (e.g., cell death/proliferation, migration, cytotoxicity, degranulation, live cell analysis, multiplex cytokine assay, and multi-color flow cytometric analysis of immune cells).
  • Hands-on experience in manipulating primary immune cells, including PBMC isolation, cell sorting, transfection/transduction, and cell activation.
  • Experience and understanding of in vivo MOA, dosing and efficacy study design, and hands-on experience in ex-vivo tissue and tumor analysis.
  • Ability to work independently and collaboratively with cross-functional teams to deliver the timely study results.
  • Drug development experience in antibodies, nuclear acid, cellular therapy, or small molecules is a plus.
  • Multitasking skills in a fast-paced environment.